Methotrexate Prescription: What You Need to Know

If your doctor just wrote a methotrexate prescription, you might be wondering what comes next. Methotrexate is a powerful drug used for arthritis, psoriasis, and some cancers. It works by slowing down cell growth, which helps reduce inflammation or stop tumor cells from multiplying.

How Doctors Decide the Dose

Dosage is never one‑size‑fits‑all. For rheumatoid arthritis, doctors usually start with a low weekly dose—often 7.5 or 10 mg—and then adjust based on how you feel and what lab tests show. Cancer treatments use much higher amounts, sometimes given once every few weeks. The key is the weekly schedule; taking methotrexate daily can be dangerous.

Blood tests are a routine part of the process. Your doctor will check liver enzymes, kidney function, and blood cell counts before each refill. If any numbers are out of range, the dose may be lowered or the drug paused.

Common Side Effects and How to Manage Them

Because methotrexate affects fast‑growing cells, you might notice mouth sores, nausea, or a mild rash. These usually improve after a few weeks as your body adjusts. Taking the pill with food or a glass of water can ease stomach upset. Some people find a folic acid supplement helpful—most doctors recommend a weekly folic acid dose to protect against certain side effects.

Serious side effects are rare but can happen. Watch for persistent fever, unusual bruising, or severe abdominal pain. If any of these pop up, call your doctor right away. It’s also important to avoid alcohol while on methotrexate, as it can stress the liver.

Pregnancy is a no‑go zone with methotrexate. The drug can harm a developing baby, so both men and women need to use reliable contraception during treatment and for at least three months after stopping.

In short, a methotrexate prescription means you have a strong medication that can bring big relief if used correctly. Follow your doctor’s schedule, keep up with lab work, and talk openly about any side effects. With the right plan, methotrexate can be a game‑changer for managing chronic inflammation or fighting certain cancers.